فهرست پایان نامه استنتاج شبکه های تنظیمات ژنی از روی داده های سری زمانی Microarray به وسیله شبکه های بیزین دینامیک
فهرست:
فصل اول: مقدمه 1
ضرورت انجام کار 6
نگاه کلی به فصول رساله 6
فصل دوم: پیشینه تحقیق 8
2-1- مقدمه 9
2-2- مقدمات زیستی 9
2-2-1- ژن 9
2-2-2- بیان ژن 10
2-2-3- شبکه های تنظیم کننده ژنی 11
2-3- روش های یاد گیری شبکه های تنظیم کننده ژنی 12
2-3-1- روش های مبتنی بر خوشه بندی 12
2-3-2- روش های مبتنی بر رگرسیون 13
2-3-3- روش های مبتنی بر اطلاعات متقابل 14
2-3-4- روش های تابعی 14
2-3-5- روش های مبتنی بر تئوری سیستم 14
2-3-6- روش های بیزین 15
فصل سوم: روش پیشنهادی 18
3-1- مقدمه 19
3-2- شبکه های بیزین دینامیک 20
3-3- یادگیری شبکه های بیزین دینامیک 22
3-3-1- روش های امتیازدهی بیزین 23
3-3-1-1- امتیازدهی به روش K2 25
3-3-1-2- امتیازدهی به روش BDe 26
3-3-2- روش های امتیازدهی بر اساس تئوری اطلاعات 26
3-3-2-1- امتیازدهی به روش log-likelihood (LL) 27
3-3-2-2- امتیازدهی به روش BIC 27
امتیازدهی به روش AIC 28
3-3-2-4- امتیازدهی به روش MIT 28
- پیچیدگی زمانی یادگیری شبکه های بیزین دینامیک 29
3-4- شبکه های تصادفی و شبکه های Scale-free 31
3-5- روش پیشنهادی 35
فصل چهارم: نتایج تجربی 44
4-1- مقدمه 45
4-2- روش های تولید شبکه های Scale-free 46
4-3- روش های سنجش دقت برای شبکه های استنتاج شده 50
4-4- آزمایش اول: استفاده از روش جستجوی کامل 52
4-5- آزمایش دوم: نگاهی دقیق تر به عملکرد روش ارائه شده 54
4-6- آزمایش سوم: استفاده از جستجوی حریصانه 57
4-7- آزمایش چهارم: بازیابی قسمتی از شبکه تنظیمات ژنی در Yeast 60
4-8- آزمایش پنجم: : عملکرد روش ارائه شده در بازیابی شبکه های تصادفی 63
فصل پنجم: جمع بندی 67
5-1- نتیجه گیری 68
5-2- پیشنهاد برای کارهای آتی 69
منابع تحقیق 70
چکیده به زبان انگلیسی 74
منبع:
انگلیسی
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